effects of spermiogenic defects on fertilization and pregnancy rate in ivf patients
نویسندگان
چکیده
introduction: the objective of this study was to evaluate the relationship between spermiogenic defects such as protamine deficiency, and acrosomal integrity with fertilization and pregnancy rate in ivf patients. material and methods: density, motility and morpology of semen samples from 70 infertile couples undergoing ivf at isfahan fertility and infertility center were analyzed according to who criteria. protamine deficiency and acrosin activity were assessed by chromomycin a3 (cma3) and gelatinolysis test. statistical analysis was carried out using the statistical package for the social studies (spss 11.5) and p-value lower than 0.05 was considered to be significant. results: cma3 positivity, percentage halo formation, means halo diameter and sperm morphology showed a significant correlation with fertilization rate. the rate of halo formation and mean halo diameter showed a significant correlation with cma3 positivity. none of the parameters were significantly different between pregnant and non - pregnant patients. however, the rate of halo formation showed a closely significant difference (r=0.306; p=0.058). conclusion: the results of the present study indicate that sperm acrosomal integrity assessed by percentage halo formation has profound effects on pregnancy outcome in ivf procedure.
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Effects of Thyroid Stimulating Hormone (TSH) level on clinical pregnancy rate via In Vitro Fertilization (IVF) procedure
Background :Subclinical hypothyroidism may adversely affect In Vitro Fertilization (IVF) outcomes. However the cutoff of thyroid-stimulating hormone (TSH) for diagnosis and treatment is controversal. The aim of this study was to find the association of clinical pregnancy rate with regard to TSH levels in women undergoing IVF. Methods: A historical cohort study of 816 infertile patients who ...
متن کاملEffects of Sperm Acrosomal Integrity and Protamine Deficiency on In Vitro Fertilization and Pregnancy Rate
Background The objective of this study was to evaluate the relationship between protamine deficiency, and acrosomal integrity with fertilization and pregnancy rate in patients undergone in vitro fertilization (IVF). MaterialsAndMethods Semen samples from 70 infertile couples undergoing IVF at Isfahan Fertility and Infertility center were assessed in this study. Semen analysis was carried out ac...
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متن کامل
Effects of Thyroid Stimulating Hormone (TSH) level on clinical pregnancy rate via In Vitro Fertilization (IVF) procedure
BACKGROUND Subclinical hypothyroidism may adversely affect In Vitro Fertilization (IVF) outcomes. However the cutoff of thyroid-stimulating hormone (TSH) for diagnosis and treatment is controversal. The aim of this study was to find the association of clinical pregnancy rate with regard to TSH levels in women undergoing IVF. METHODS A historical cohort study of 816 infertile patients who unde...
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عنوان ژورنال:
cell journalجلد ۹، شماره ۲، صفحات ۱۰۳-۱۱۰
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